تاثیر ژل فوم بر میزان فیبروز اپیدورال به‌دنبال لامینکتومی در خرگوش
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Abstract:
Background: Epidural fibrosis (EF) is a part of normal physiological tissue response to laminectomy and it may be an important cause of failed back surgery syndrome (FBSS). The objective of this study was to evaluate the effect of using gel foam after laminectomy on reduction of epidural fibrosis. Methods: In this prospective study forty five rabbits were recruited. The cases undergone bilateral laminectomy at the L4 and L5 lumbar levels under an approved surgical protocol. After eight weeks the rabbits were sacrificed and the spinal segments from L3 to L6 were removed en bloc. The amount of scar tissue at the laminectomy defect was scored. The fibroblast and inflammatory cell counts were also compared between two groups. Results: In this study 55% of group A rabbits were placed in grade 0 or I, grade II fibrosis could be detected in the remaining 45%. In group B these amounts were 73.7% and 26.3% respectively, which no significant statistical difference could be detected between two arms (p=0.189). Comparing the quantity of fibroblasts 40% of group A rabbits were recognized as grade I and the other 60% as grade II and grade I fibrosis was discovered in 42.1% of group B rabbits, while other 57.9% suffered from grade II fibrosis, again no significant statistical difference could be attributed between two arms (p=0.576). Also comparing inflammatory cell counts detected in the specimens no significant statistical difference could be detected either (p=0.465). Conclusion: According to this study using gel foam during the laminectomy surgery in rabbits has no obvious effect in reducing post laminectomy epidural fibrosis after eight weeks of follow-up.
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ارزیابی فیبروز اپیدورال ناشی از لامینکتومی پس از بکار بردن سیلیکون و تفلون در فضای پری دورال موش صحرایی
There are many studies about epidural fibrosis after surgical manipulation of the spine. We have studied formation of the post laminectomy epidural fibrosis after application of two materials (Silicone and Teflon) in this report. This expriment is on two groups of rats. Two separated laminectomies were done in each rat, one serving as control while in the other laminectomy spaces Silicone was u...
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سابقه و هدف : نظر به اینکه لامینکتومی کمری یکی از اعمال جراحی شایع در بیماران جراحی اعصاب ستون فقرات می باشد، شناخت عوارض آن از اهمیت بالایی برخوردار است. یکی از عوارض نسبتاً نادر در این بیماران، هماتوم اپیدورال ناحیه عمل می باشد که عدم تشخیص و درمان بموقع آن عوارض بسیار جدی و ناتوان کننده ای بهمراه خواهد داشت. مواد و روشها : در این مطالعه گذشته نگر، 2900 بیمار که در فاصله ساهای 1367 لغایت 1379 ...
full textبررسی تاثیر افزودن نئوستیگمین به لیدوکایین بر میزان دردهای پس از عمل در بیهوشی اپیدورال
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Background: Topically applied tranexamic acid has been shown to decrease the amount of blood loss associated with major spinal surgical procedures. The aim of this study was to evaluate the effects of locally applied tranexamic acid in epidural space on post-laminectomy blood loss. Methods: One hundred patients who were scheduled to undergo laminectomy in Imam Khomeini Hospital in T...
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Journal title
volume 66 issue None
pages 791- 796
publication date 2009-02
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